Located halfway between Halifax and Sydney enroute to Cape Breton, DesBarres Manor Inn is only 25 minutes off the Trans-Canada Highway (Hwy 104). Travelling from the Halifax International Airport, take Exit 37 approximately 20 minutes past Antigonish at Monastery. Turn south onto Highway 16, which leads directly into the beautiful seaside village of Guysborough.

DesBarres Manor Inn is a leisurely 4 hour drive from Halifax along the Eastern Shore following the scenic Marine Drive Trail.